反应详情

Benzyl 3-(4-benzyloxyphenyl)propionate (9.25 g) and a solution of 2.8 g potassium hydroxide in 95% ethanol (125 ml) were placed in a flask, and the mixture was heated under reflux for 30 minutes. At the end of reaction, the solvent was distilled off, ethyl acetate was added to the residue, and the resulting mixture was transferred to a separating funnel. After washing with 1N HCl and water, the ethyl acetate layer was collected and dried over anhydrous sodium sulfate, the solvent was distilled off from the dried solution, and the residue was recrystallized from ethyl acetate/hexane, affording 5 g (72.7%) of pure 3-(4-benzyloxyphenyl)propionic acid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 30 minutes
3. customAt the end of reaction
4. distillationthe solvent was distilled off
5. additionethyl acetate was added to the residue
6. customthe resulting mixture was transferred to a separating funnel
7. washAfter washing with 1N HCl and water
8. customthe ethyl acetate layer was collected
9. dry with materialdried over anhydrous sodium sulfate
10. distillationthe solvent was distilled off from the dried solution
11. customthe residue was recrystallized from ethyl acetate/hexane