Dimethylformamide → Cephalexin ethanol

Participants

Reaction Steps

A slurry of 47.4 g of cephalexin bis-DMF solvate in 600 ml of 3A ethanol (K.F=0.03%) was stirred at room temperature and seeded with a few milligrams of a product from an earlier like preparation. After stirring the mixture 5 hours at room temperature, the ethanol in the mixture was evaporated until the total weight of the resulting slurry was 230 g. Filtration provided a crystalline cephalexin ethanol solvate. Air drying the product overnight, provided 35.1 g of crystalline desolvated cephalexin ethanolate.

Provenance & Evidence