HCID 86742466, compound → HCID 86742465, compound

Participants

Reaction Conditions

Reaction Steps

(S)-2-Diethylaminopropanol hydrochloride (50 g) is added in small portions to thionyl chloride (110 cc) at 2° C. The solution obtained is then heated to 60° C. for 4 hours. Excess thionyl chloride is removed by distillation under reduced pressure (90 kPa) and ethyl ether (250 cc) is then added to the residue obtained. The resultant solid is filtered off, is rinsed with ethyl ether (300 cc) and is then recrystallized from methyl isobutyl ketone (150 cc). After filtration and washing with ethyl ether, (S)-2-diethylamino-1-chloropropane hydrochloride (45.6 g) is obtained in the form of white crystals melting at 103° C., [α]D20 =0 (c=0.7; ethanol).

Provenance & Evidence