反应详情

温度

80 °C

A mixture of 4.00 g (20 mmol) of 2-chloro-6-(1H-1,2,3-triazol-1-yl)pyridine and 8.5 ml of sodium methoxide (25 percent in methanol, 40 mmol) in dimethyl sulfoxide was heated at 80° C. for six hours. The mixture was cooled, poured over ice and extracted with methylene chloride. The extract was dried over magnesium sulfate and stripped of solvent. The solid residue was triturated in a minimal amount of methanol and filtered to yield 0.4 g (10 percent of theory) of tan solid product; m.p., 75°-78° C. NMR (CDCl3): δ8.60 (s, 1H); δ7.94 (m, 3H); δ6.90 (m, 1H); δ4.06 (s, 3H).

1. temperatureThe mixture was cooled
2. additionpoured over ice
3. extractionextracted with methylene chloride
4. dry with materialThe extract was dried over magnesium sulfate
5. customThe solid residue was triturated in a minimal amount of methanol
6. filtrationfiltered
7. customto yield 0.4 g (10 percent of theory) of tan solid product
8. customm.p., 75°-78° C