Water → HCID 14249914, compound

Participants

Reaction Steps

A mixture of 1-(thien-3-yl)chloroethane (5.0 g, 34 mmol) and sodium azide (2.65 g, 41 mmol) in DMF was stirred at room temperature for three days. The reaction mixture was poured into H2O (500 ml) and extracted with CH2Cl2 (3×200 ml). The organic extracts were washed with H2O (5×100 ml), dried over MgSO4 and concentrated in vacuo to give the product (5.02 g, 96% yield) as a brown oil; IR (neat) 2110 cm-1 ; 1H NMR (CDCl3) δ1.55 (d, J=7 Hz, 3H, CHCH3), 4.67 (q, J=7 Hz, 1H, CHCH3), 6.98-7.43 (m, 3H, thiophene-H).

Provenance & Evidence