Sodium Cyanate → HCID 178433485, compound

Participants

Reaction Steps

Sodium cyanate (0.50 g, 7.69 mmol) was added to a solution of crude 7-amino-4-methylthieno[3,2-c]pyridin-6-ol (1.26 g, 7.00 mmol) in acetic acid (30 ml) and an off-white solid precipitated. This mixture was stirred for one hour at room temperature. The solid was collected by filtration, washed with acetic acid, triturated with refluxing MeOH, then refluxing Et2O, and dried in vacuo to give the urea (0.798 g, 51% yield); mp 294°-297° C. (dec); IR (KBr) 1525, 1620 and 2300-3100 cm-1 ; mass spectrum m/z 223 (M+); 1H NMR (TFA) δ3.02 (s, 3H, 4-CH3), 7.63 and 7.77 each (d, J=6 Hz, 1H, thiophene-H).

Provenance & Evidence