HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-Amino-2,3-dimethylbutanamide → 5-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-Amino-2,3-dimethylbutanamide | HCID 10154071 | — |
| Reactant | 5-Acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride | HCID 13799444 | — |
| Product | 5-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid | HCID 13799445 | — |
Reaction Steps
6.3 g (28.48 mmol) 5-acetoxy-6-methyl-pyridine-2,3-dicarboxylic acid anhydride and 4.1 g (31.33 mmol) 2-methylvalinamide are stirred under nitrogen for 2 days at room temperature, and then the precipitated crystalline product is filtered off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04776876 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-a2dc49e09999486c88245e2164b8b648 |
| Source note | uspto-grants-1988_10 |