Dimethylamine → HCID 21245795, compound

HRID 867884Notes

Reaction equation

HRID 867884 reaction equation
[CH3:1][NH:2][CH3:3].[CH3:4][O:5][CH2:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[CH:9][N:8]=1.O>C(O)C>[CH3:4][O:5][CH2:6][C:7]1[N:12]=[C:11]([N:2]([CH3:3])[CH3:1])[CH:10]=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 14306130105950-89-8

Product 1

HCID 21245795HCID 21245795, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A 33% w/w solution of dimethylamine in ethanol (45 ml) was added dropwise to a stirred solution of 2-methoxymethyl-4-chloropyrimidine (7.54 g) in ethanol (100 ml), cooled over an ice bath. The mixture was allowed to warm to room temperature, and left to stand for 16 hours. After stripping, the residue was treated with water (100 ml), and extracted with chloroform. The extracts were dried (K2CO3) and stripped to give 2-methoxymethyl-4-dimethylaminopyrimidine (7.41 g) as an oil.

Workup

  1. temperaturecooled over an ice bath
  2. waitleft
  3. extractionextracted with chloroform
  4. dry with materialThe extracts were dried (K2CO3)

Sources & evidence

ORD record
ord-d2634161cced4f65a50c6b67b1701db8
Source dataset
uspto-grants-1988_10
Patent number
US04777172

Reaction notes

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