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Thionyl Chloride → 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-Pyrimidinemethanol,5-methyl-6-(1-piperidinyl)- | HCID 14306162 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride | HCID 21245798 | — |
反応手順
Thionyl chloride (4.5 ml) in chloroform (30 ml) was added dropwise to a stirred solution of 4-hydroxymethyl-5-methyl-6-piperidinopyrimidine (4.24 g) in chloroform (30 ml) cooled in an ice-salt bath. The mixture was allowed to warm to room temperature and stirred for a further 22 hours. The solution was stripped to a residual glass which was triturated with diethyl ether to give 4-chloromethyl-5-methyl-6-piperidino-pyrimidine hydrochloride, 5.24 g, m.p. 182°-184°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04777172 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-3dfef1f76be140aea984410b155964d4 |
| 出典メモ | uspto-grants-1988_10 |