Hydrochloric Acid → HCID 21289105, compound

Participants

Reaction Steps

3.8 g of 4-fluoro-N-tert.-butoxycarbonylamino-isoindoline are introduced into 30 ml of concentrated hydrochloric acid at room temperature. The mixture is subsequently stirred at room temperature for 1 hour and the solvent is then distuilled off in vacuo. The residue is treated with hot i-propanol; after cooling to 10° C., the precipitate is filtered off with suction. 2.1 g of 2-amino-4-fluoro-isoindoline hydrochloride are obtained.

Provenance & Evidence