Hydrochloric Acid → HCID 178443209, compound

Participants

Reaction Steps

2-(4-n-Butylsulfonamidophenoxy)-n-dodecanoyl chloride (16.6 g, 35 mmole) in THF (35 ml) was added to a suspension of the product of part (b) (11.9 g, 35 mmole) and sodium bicarbonate (4.2 g) in THF (95 ml). After 22 hours, more THF (45 ml) and potassium hydroxide (7.9 g, 140 mmole) in water (175 ml) were added and stirring continued for a further 80 minutes. 3M HCl (100 ml) was added and the THF removed by evaporation under reduced pressure. Dichloromethane (250 ml) was added and the organic extract separated, washed with saturated NaCl, (2×150 ml) dried and evaporated to give the product 23.7 g (92%) m.p. 117°-120° C.

Provenance & Evidence