Water → N-[[5-(1,3-Dioxolan-2-yl)-4-methyl-2-thienyl]-4-butyl]isoindole-1,3(2H)-dione

Participants

Reaction Steps

2-[5-(4-Bromobutyl)-3-methyl-2-thienyl]-1,3-dioxolane (13.3 g) and potassium phthalimide (8.9 g) were stirred at 50° in dry dimethylformamide (130 ml) for 4 h and then at room temperature for 18 h. The mixture was poured into water (1500 ml) and extracted with ether. The organic extract was evaporated to give the title compound as a light yellow oil (16.1 g)

Provenance & Evidence