Hydrazine hydrate (1:1) → 4-[5-(1,3-Dioxolan-2-yl)-4-methyl-2-thienyl]-butanamine

Participants

Reaction Steps

N-[[5-(1,3-Dioxolan-2-yl)-4-methyl-2-thienyl]-4-butyl]-isoindole-1,3(2H)-dione (16.1 g) and hydrazine hydrate (8 ml) were stirred at room temperature in tetrahydrofuran (150 ml) for 24 h. The mixture was filtered and the filtrate was distilled to give the title compound as a red-brown oil (5.34 g), b.p. 230°/0.1 mm.

Provenance & Evidence