N-bromobutanimide → HCID 13822033, compound

Participants

Reaction Steps

A mixture of 3.0 g (8.5 mmol, m.p. 110°-112° C.) of 1-butyl-N-(2,6-diethylphenyl)-1,4-dihydro-2,6-dimethyl-4-oxo-3-pyridinecarboxamide and 1.7 g (9.6 mmol) of N-bromosuccinimide was dissolved in 100 ml of dichloromethane, and the mixture was stirred for a day at room temperature. The reaction mixture, transferred to a separatory funnel, was washed with water, saturated sodium bicarbonate and water. The organic layer was dried and concentrated in a known manner to give a crystalline residue, and the residue was recrystallized from a mixture of ethyl acetate and hexane, affording 2.25 g of the title compound having m.p. 158°-160.5° C.

Provenance & Evidence