2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole → HCID 70274702, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 7.07 g (27.5 mmol) of 1,1-diphenoxy-2-nitroethene in 70 ml of tetrahydrofuran was stirred at 25° C. To this solution was added a mixture of 6.83 g (27.5 mmol) of 93% pure 4-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine in 100 ml of isopropyl alcohol. The reaction mixture was stirred for approximately one hour at 25° C. and the progress of the reaction was followed by thin-layer chromatography to provide N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-2-nitro-1-phenoxy-1-etheneamine. The product was not isolated but rather used directly in the following reaction.

Provenance & Evidence