2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole → HCID 70274702, compound

Participants

Reaction Steps

According to the general procedure of Example 2, a solution of 1.65 (6.8 mmol) of 95% pure 4-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine and 1.8 g (7.0 mmol) of 1,1-diphenoxy-2-nitroethene dissolved in 25 ml of methylene chloride was stirred at room temperature for about two hours to provide N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-2-nitro-1-phenoxy-1-etheneamine in situ. This compound was reacted with gaseous monomethylamine to provide 0.8 g of nizatidine. Yield 35.5%.

Provenance & Evidence