HCID 13607600, compound → HCID 21289480, compound

HRID 868006Notes

Reaction equation

HRID 868006 reaction equation
BrC1C=CC=C2C=1CCCC2[CH2:12][CH2:13][OH:14].Cl.N1C=CC=C(CC2CCC3C=C([C:33](O)=[O:34])C=CC=3C2)C=1.[S:36]1[C:40]([CH2:41][CH2:42][CH:43]2[CH2:52][CH2:51][CH2:50][C:49]3[CH:48]=[C:47](C([O-])=O)[CH:46]=[CH:45][C:44]2=3)=[CH:39][N:38]=[CH:37]1.[Na+].Cl.[N:58]1(CCC2CCCC3C(C(O)=O)=CC=CC2=3)C=CN=C1>>[NH2:58][C:37]1[S:36][C:40]([CH2:41][CH2:42][CH:43]2[CH2:52][CH2:51][CH2:50][C:49]3[C:48]([C:33]([O:14][CH2:13][CH3:12])=[O:34])=[CH:47][CH:46]=[CH:45][C:44]2=3)=[CH:39][N:38]=1

Participants

5

Reactant 4

HCID 13607600HCID 13607600, compoundHCID 13671507HCID 13671507, compound2×HCID 21289493HCID 21289493, compoundHCID 23685138HCID 23685138, compound

Product 1

HCID 21289480HCID 21289480, compound

Procedure

5-bromo-1-(2-hydroxyethyl)-1,2,3,4-tetrahydronaphthalene was allowed to react using procedures analogous to those described in step (7) of Referential Example 1, steps (2) and (3) of Referential Example 2, steps (3), (4), (5) and (6) of Referential Example 1 and steps (5) and (6) of Referential Example 2 to give ethyl 5-(2-(2-amino-5-thiazolyl)ethyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxylate as an oil.

Workup

  1. customto react

Sources & evidence

ORD record
ord-cf2a49dba59d4cd493b9a4acfa849812
Source dataset
uspto-grants-1988_10
Patent number
US04777257

Reaction notes

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