7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → 1-Ethyl--6-fluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

HRID 868052Notes

Reaction equation

HRID 868052 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10](Cl)[N:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].Cl.Cl.[CH2:21]([N:23]1[CH2:27][CH2:26][C:25]2([CH2:31][CH2:30][NH:29][CH2:28]2)[CH2:24]1)[CH3:22]>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10]([N:29]3[CH2:30][CH2:31][C:25]4([CH2:26][CH2:27][N:23]([CH2:21][CH3:22])[CH2:24]4)[CH2:28]3)[N:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 127908597-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 134918112-Ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride

Product 1

HCID 137727451-Ethyl--6-fluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

Procedure

The title compound was prepared according to example 24 by reacting 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid with 2-ethyl-2,7diazaspiro[4.4]nonane dihydrochloride; mp 215°-217° C.(dec).

Sources & evidence

ORD record
ord-601905dd99924693b67b1b16ee1f7a25
Source dataset
uspto-grants-1988_10
Patent number
US04777175

Reaction notes

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