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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 868053Generated: October 29, 2026

1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acid

https://huagongshe.com/reaction/868053

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 9835179—
Reactant2-Ethyl-2,7-diazaspiro[4.4]nonane dihydrochlorideHCID 13491811—
Product1-Ethyl-6,8-difluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acidHCID 13772762—

Reaction Steps

The title compound was prepared according to example 26 by reacting 1-ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid with 2-ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride, mp 199°-202° C. (dec).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04777175
Source datasetuspto-grants-1988_10
ORD IDord-86f61f7306544609ab7fc715b3ea959d
Source noteuspto-grants-1988_10