HCID 13772778, compound → HCID 53942979, compound

Participants

Reaction Steps

In similar fashion the following compounds were prepared: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-[2-[(methylamino) methyl]-4-thiazolyl]-4-oxo-3-quinolinecarboxylic acid, mp 172°-174° C. (35a); 7-[2-[(ethylamino)methyl]-4-thiazolyl]-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 155°-157° C. (35b); 7-[2-(aminomethyl)-4-thiazolyl]-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 216°-218° C. (35c); 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-[2[(methylamino)methyl]-4-thiazolyl]-4-oxo-3quinolinecarboxylic acid, mp 214°-215° C. (35d); 7-[2-[(ethylamino)methyl]-4-thiazolyl]-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp 197°-201° C. (35e), and 10-[2-(aminomethyl)-4-thiazolyl]-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, mp 229°-231° C. (35f).

Provenance & Evidence