(1-Benzyl-pyrrolidin-3-ylmethyl)-isopropyl-amine → N-(Pyrrolidin-3-ylmethyl)propan-2-amine

Participants

Reaction Steps

A mixture of 13.4 g (58.0 mmol) of 1-phenylmethyl-N-(2-propyl)-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 130 ml of methanol was shaken in an atmosphere of hydrogen at about 4.5×105Pa and room temperature for 24 hours. The catalyst was removed by filtration through Celite; the filtrate concentrated and distilled in vacuo to give 6.3 g of N-(2-propyl)-3-pyrrolidinemethanamine, bp 58°-60° C./3.5 mm.

Provenance & Evidence