HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 13772860, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 13772857 | HCID 13772857 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 13772860 | HCID 13772860 | 100% |
Reaction Steps
A solution of 0.50 g (2.44 mmol) [3R-(R*,R*)]-1-(1-phenylethyl)-3-pyrrolidinemethanol in 5 ml 1,2-dichloroethane was treated with 2 ml thionyl chloride, refluxed two hours, evaporated, and crystallized by trituration with ether to afford 0.64 g (100%) of the title compound as the hydrochloride mp 140°-146 ° C., [α]D +27.8° C. (c, 1.07, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04777175 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-b0d13626d303410c82b3878db19c4348 |
| Source note | uspto-grants-1988_10 |