HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4,5-bis(phenylmethoxy)-2-Pyridinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl 4,5-bis(benzyloxy)pyridine-2-carboxylate | HCID 14182499 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4,5-bis(phenylmethoxy)-2-Pyridinecarboxylic acid | HCID 14182507 | — |
Reaction Steps
To a solution of 11.8 g (28 mmol) of 4,5-bis(phenylmethoxy)-2-pyridinecarboxylic acid, phenylmethyl ester in 115 ml of tetrahydrofuran were added 16 ml water and 35 ml of 1N potassium hydroxide. After stirring overnight at room temperature, 115 ml water was added and the pH was adjusted to 2.5 with 1N hydrochloxic acid. The acid was filtered off, washed with water and dried in vacuo. Yield: 8.6 g; melting point 203.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04777252 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-6edb9b2d78d84634810672dfcf23608b |
| Source note | uspto-grants-1988_10 |