tert-Butanol → [4,5-Bis(phenylmethoxy)-2-pyridinyl]carbamic acid, 1,1-dimethylethyl ester

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1.5 g (4.5 mmol) of 4,5-bis(phenylmethoxy)-2-pyridinecarboxylic acid in 25 ml of t-butanol were added 1.5 g (5.4 mmol) of diphenylphosphoryl azide and 0.54 g (5.4 mmol) of triethylamine. The mixture was stirred at 80° C. for 17 hours. After cooling to room temperature, the crystals were filtered off, washed with ether and dried in vacuo. Yield: 1.3 g. Concentration of the mother liquor yielded another 0.3 g of product. Total yield: 1.6 g; melting point 163.3° C.

Provenance & Evidence