Sodium Hydroxide → HCID 14278968, compound

HRID 868166Notes

Reaction equation

HRID 868166 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[CH:11]=[N:10][C:9]([C:17]([O:19]C)=[O:18])=[CH:8]2>O.O.O1CCCC1>[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[CH:11]=[N:10][C:9]([C:17]([OH:19])=[O:18])=[CH:8]2

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 11096910HCID 11096910, compound

Product 1

HCID 14278968HCID 14278968, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21881883Oxolane--water (1/1)Solvent

Procedure

A solution of sodium hydroxide (4.38 g, 109.4 mmol) in 70 ml of water was added to a solution of 6,7-dimethoxy-3-isoquinolinecarboxylic acid, methyl ester (22.54 g, 91.2 mmol) in 1800 ml of water:tetrahydrofuran 1:1. After stirring overnight at room temperature, the tetrahydrofuran was distilled off in vacuo and the pH of the remaining aqueous solution was brought to 3 with 3N hydrochloric acid. The resulting precipitate was filtered off with suction, washed with water and dried in vacuo. Yield: 19.57 g; melting point 228.2° C.

Workup

  1. distillationthe tetrahydrofuran was distilled off in vacuo
  2. filtrationThe resulting precipitate was filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-b64f8fad54da4ef9a399b51e4ade7450
Source dataset
uspto-grants-1988_10
Patent number
US04777252

Reaction notes

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