5-Bromopyridine-2-carboxylic acid → (5-{3-[(5-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

HRID 86819Notes

Reaction equation

HRID 86819 reaction equation
[Br:25][c:26]1[cH:27][cH:28][c:29]([C:32](=[O:33])[OH:34])[n:30][cH:31]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[cH:18][c:19]([NH2:23])[cH:20][cH:21][cH:22]2)[CH2:11][O:10][CH2:9]1)=[O:24]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[cH:18][c:19]([NH:23][C:32]([c:29]3[cH:28][cH:27][c:26]([Br:25])[cH:31][n:30]3)=[O:33])[cH:20][cH:21][cH:22]2)[CH2:11][O:10][CH2:9]1)=[O:24]

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 66665306[5-(3-Amino-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Product 1

HCID 66665434(5-{3-[(5-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-89d5354b356547c0a8c3b10ac27bf2cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…