Ethanol → HCID 21288067, compound

HRID 868207Notes

Reaction equation

HRID 868207 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH:20]([O:22][CH2:23][CH3:24])[CH3:21])[CH:14]=[CH:13][CH:12]=3)=[O:5])C.[OH-].[Na+].C(O)C>C(O)(=O)C>[CH2:23]([O:22][CH:20]([C:15]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:16]=1[C:17]1[C:18]([CH3:19])=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[CH:8][C:9]=1[NH:10]2)[CH3:21])[CH3:24]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13765250HCID 13765250, compound

Product 1

HCID 21288067HCID 21288067, compoundYield 87.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

500 mg of 5-(1-ethoxyethyl)-4-methyl-beta-carboline-3-carboxylic acid ethyl ester was refluxed with 5 ml of 1N sodium hydroxide solution and 20 ml of ethanol for 3 hours. Then it was acidified with glacial acetic acid, suctioned off and washed with water. 400 mg of 5-(1-ethoxyethyl)-4-methyl-beta-carboline-3-carboxylic acid was obtained, which after good drying over phosphorus pentoxide in a vacuum was further reacted.

Workup

  1. washwashed with water

Sources & evidence

ORD record
ord-b436564796964fe29a650c645e8a94f1
Source dataset
uspto-grants-1988_10
Patent number
US04778800

Reaction notes

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