4-Amino-1-(2-naphthyl)methylpiperidine → HCID 13853616, compound

Participants

Reaction Steps

A suspension of 4-amino-1-(2-naphthalenylmethyl)piperidine (1.4 g, 5.83 mmol) and N-aminocarbonyl-6-quinolinecarboxamide (1.08 g, 5.02 mmol) in pyridine (7 cm3) was refluxed for 7 hours. The mixture was left at room temperature overnight then more 4-amino-1-(2-naphthalenylmethyl)piperidine (0.3 g, 1.4 mmol) was added and refluxing was continued for 5 hours. Undissolved solid was filtered off from the hot mixture and the filtrate was diluted with water (8 cm3) and filtered again. The filtrate was further diluted with water and cooled in ice. The deposited solid was collected and dried (0.46 g,) then recrystallised from ethanol (50 cm3) to give 0.30 g of the title compound, m.p. 211°-13° C.

Provenance & Evidence