反应详情

温度

25 °C

Sodium borohydride (1.368 g, 36 mmole) was added portionwise to a solution of 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-one, prepared by the process of Example 1, Step 1, (2.22 g, 12 mmole) in methanol (200 mL). The reaction mixture was stirred at 25° C. for 2 hours, evaporated to near-dryness, and the residue suspended in water (150 mL). The product was extracted with chloroform (3×75 mL), and the combined organic layer dried over MgSO4, filtered, and evaporated to dryness. The residue was crystallized from ether to afford 1.32 g (59%) of product, m.p. 118.5°-120° C., as an off-white solid.

1. customevaporated to near-dryness
2. extractionThe product was extracted with chloroform (3×75 mL)
3. dry with materialthe combined organic layer dried over MgSO4
4. filtrationfiltered
5. customevaporated to dryness
6. customThe residue was crystallized from ether