Sodium Hydroxide → HCID 14301765, compound

HRID 868246Notes

Reaction equation

[OH-].[Na+].Cl.Cl.C([O:7][C:8]([C@@H:10]([NH:21][C@H:22]1[CH2:28][S:27][C@H:26]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[CH2:25][N:24]([CH2:34][C:35]([OH:37])=[O:36])[C:23]1=[O:38])[CH2:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)=[O:9])C>>[C:8]([C@@H:10]([NH:21][C@H:22]1[CH2:28][S:27][C@H:26]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[CH2:25][N:24]([CH2:34][C:35]([OH:37])=[O:36])[C:23]1=[O:38])[CH2:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)([OH:9])=[O:7]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67825849HCID 67825849, compound

Product 1

HCID 14301765HCID 14301765, compoundYield 76.6%

Procedure

1.54 ml of a 1N aqueous solution of sodium hydroxide was added to 150 mg of α-{6(R)-[1(S)-ethoxycarbonyl5-(4-piperidyl)pentylamino]-5-oxo-2(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid dihydrochloride (prepared as described in Example 19), and the mixture was stirred at room temperature for 17 hours. At the end of this time, the reaction mixture was adjusted to a pH value of 4.7 by adding 1N aqueous hydrochlodric acid, and the precipitate was collected by filtration, to give 95 mg of the title compound.

Workup

filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record: ord-005894ba745742dd990ba1b5c9da4339
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04778790

Reaction notes

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