p-Anisoyl chloride → HCID 14257798, compound

Participants

Reaction Steps

To p-anisoyl chloride (205 g) in 1,2-dichloroethane (2 L), cooled to 0° C., was added AlCl3 (240 g). The reaction mixture was warmed to room temperature and a solution of 7-hydroxy-3,5,6-trimethylbenzofuran (51 g) in 1,2-dichloroethane (400 mL) was added dropwise. The reaction was stirred for 51/2 h then quenched with H2O (2 L). The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined extracts were washed with 25% NH4OAc buffer, dried (Na2SO4) and filtered on silica gel to give 170 g of crude material which was used as such in the next step.

Provenance & Evidence