Nitric Acid → 2-Chloro-4-fluoro-3-methyl-1-nitrobenzene

HRID 868265Notes

Reaction equation

HRID 868265 reaction equation
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=1[CH3:18]>>[Cl:10][C:11]1[C:16]([N+:6]([O-:9])=[O:7])=[CH:15][CH:14]=[C:13]([F:17])[C:12]=1[CH3:18]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 99332-Chloro-6-fluorotoluene

Product 1

HCID 132515092-Chloro-4-fluoro-3-methyl-1-nitrobenzene

Conditions

Temperature
15 °C

Procedure

To a vigorously stirred mixture of sulphuric acid (136 ml) and nitric acid (134 ml), maintained at 15° C. was added dropwise 2-chloro-6-fluorotoluene (100 g) over a period of 30 minutes. The mixture was alllowed to attain room temperature (20° C.), stirred for 70 minutes, then poured onto crushed ice. Solid 2-chloro-6-fluoro-3-nitrotoluene (70 g) was obtained after filtering and drying.

Workup

  1. customto attain room temperature
  2. custom(20° C.)
  3. additionpoured
  4. customonto crushed ice

Sources & evidence

ORD record
ord-4d91f5db3bbc41948ae4ff1ff264d9cd
Source dataset
uspto-grants-1988_10
Patent number
US04778822

Reaction notes

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