HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-(Bromomethyl)-3-chloro-1,4-difluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Chloro-1,4-difluoro-3-methylbenzene | HCID 13251513 | — |
| Catalyst | Tungsten | HCID 23964 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-(Bromomethyl)-3-chloro-1,4-difluorobenzene | HCID 2773549 | 81.9% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of bromine (24.4 g) in carbon tetrachloride (50 ml) was added slowly over a period of 2 hours 45 minutes to a vigorously stirred solution of 2-chloro-3,6-difluorotoluene (24.4 g) in carbon tetrachloride (150 ml) irradicated by a 200 watt tungsten lamp maintained at 0° C. The solvent was removed by evaporation under reduced pressure and the residual oil distilled to yield 2-chloro-3,6-difluorobenzyl bromide (29.7 g) b.p 96°-101°/0.7 cm Hg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04778822 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-19a83f156ab6437ba2e73938c0d0f678 |
| Source note | uspto-grants-1988_10 |