Acetyl chloride → 1-Acetyl-4-methylimidazole

Participants

Reaction Steps

50 g (0.6 mol) of 4-methylimidazole are dissolved in 500 ml of absolute ether. After dropwise addition of 23.6 g (0.3 mol) of acetyl chloride in 75 ml of absolute ether at room temperature, the mixture is heated under reflux for 11 hours. The residue is removed by filtration, and the solution is evaporated in vacuo. 11.45 g (31%) of 1-acetyl-4-methylimidazole are obtained as a colorless oil.

Provenance & Evidence