Lithium → HCID 70418137, compound

Participants

Reaction Steps

0.2 g (0.75 mmol) of methyl 6-(1-imidazolylmethyl)-2-naphthoate in 5 ml of absolute tetrahydrofuran are added dropwise to 28.5 mg (0.75 mmol) of lithium alanate in 1 ml of absolute tetrahydrofuran. The mixture is allowed to stand at room temperature overnight. Excess lithium alanate is destroyed by addition of 2N HCl. After neutralization with sodium bicarbonate, the mixture is extracted with ethyl acetate, and the ethyl acetate phase is dried and evaporated in vacuo. 0.13 g (73%) of 6-(1-imidazolylmethyl)-2-naphthylmethanol is obtained. Melting point 122°-125° C.

Provenance & Evidence