Sodium Iodide → HCID 67937927, compound

Participants

Reaction Steps

A mixture of 1.0 g of N-[3-(6-methyl-3-pyridyl)acryloyl]-3-amino-1-chloropropane, 1.0 g of 1-diphenylmethylpiperazine, 0.55 g of potassium carbonate, 0.55 g of sodium iodide, and 30 ml of methyl ethyl ketone is refluxed with stirring for 6 hours. The reaction mixture is concentrated, and 20 ml of water is added. The mixture is extracted with three 30-ml portions of chloroform. The combined extracts are dried over magnesium sulfate, and the chloroform is distilled off. The residue is chromatographed on silica gel with chloroform-methanol (30:1) to give 0.65 g of the title compound. The product is converted into the fumarate in a usual manner to give the trifumarate 3/4 hydrate of the title compound. m.p. 196°-200° C. (recrystallized from ethanol)

Provenance & Evidence