Sodium Iodide → HCID 21288002, compound

Participants

Reaction Steps

A mixture of 10.0 g of 1-diphenylmethyl-3-methylpiperazine [cf. Can. Pharm. J., 95 (8), 256 (1962)], 10.6 g of N-(4-bromobutyl)phthalimide, 6.2 g of potassium carbonate, 8.4 g of sodium iodide, and 100 ml of methyl ethyl ketone is refluxed with stirring for 4 hours. The reaction mixture is concentrated, and 100 ml of water is added. The aqueous mixture is extracted with three 100-ml portions of chloroform. The combined extracts are dried over magnesium sulfate and concentrated. The residue is chromatographed on silica gel with chloroform to give 19.2 g of 2-[4-(4-diphenylmethyl-2-methyl-1-piperazinyl)butyl]phthalimide.

Provenance & Evidence