Methanol → N-(N-Formyl-L-alpha-aspartyl)-3-phenyl-L-alanine

Participants

Reaction Steps

The second process mode comprises: condensating N-formyl-L-aspartic aicd anhydride with L-phenylalanine in water containing methanol in an amount of 6 equivalents or less to L-phenylalanine at a pH in the range of 7-12 to form N-formyl-α-L-aspartyl-L-phenylalanine; acidifying the reaction mixture successively with hydrochloric acid without isolating the N-formyl-α-L-aspartyl-L-phenylalanine so as to bring it into contact with hydrochloric acid in the presence of methanol and thereby to precipitate α-APM hydrochloride; separating the α-APM hydrochloride; and neutralizing said hydrochloride as required, thereby preparing α-APM or its hydrochloride.

Provenance & Evidence