Acetic Anhydride → HCID 21288483, compound

HRID 868425Notes

Reaction equation

HRID 868425 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]([OH:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:13]=2)[CH:5]=1.[C:26](OC(=O)C)(=[O:28])[CH3:27]>N1C=CC=CC=1>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]([O:24][C:26](=[O:28])[CH3:27])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH:13]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21288504HCID 21288504, compound

Product 1

HCID 21288483HCID 21288483, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of methyl-3-[[3-(1-hydroxyhexyl)phenoxy]methyl]benzoate (1.7 g.) in pyridine at 0° C. was added acetic anhydride (2.7 ml). The reaction was stirred for four days at room temperature. The solvent was removed in vacuo and the remaining oil was purified by HPLC on silica gel using a hexanes/ethyl acetate in 9:1 ratio as an eluent (1.1 g., 57% yield).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe remaining oil was purified by HPLC on silica gel using a hexanes/ethyl acetate in 9:1 ratio as an eluent (1.1 g., 57% yield)

Sources & evidence

ORD record
ord-eab50ec6da854381bbe7ebc0176ec963
Source dataset
uspto-grants-1988_10
Patent number
US04778931

Reaction notes

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