Acetone → HCID 54006541, compound

Participants

Reaction Conditions

Reaction Steps

Hydrogenolysis of 6.5 g (13.3 mmole) of 1-benzyl-3-octadecyl-2-(2-oxopropyl)glycerol was carried out in a mixture of 100 ml of acetic acid, 20 ml of water and 20 ml of ethanol using 2.5 g of 10% palladium carbon (50% wet) at ambient temperature under atmospheric pressure. 100 ml of acetone was added and the mixture was heated up to 50° C. Then, the catalyst was filtered off and 100 ml of 2-methylpropanol was added. Furthermore, the mixture was concentrated to dryness under reduced pressure. 100 ml of toluene was added to the residue and the mixture was again concentrated to dryness. 70 ml of hexane was added to the residue, and the crystals precipitated were collected by filtration to give 3.9 g (yield: 74%) of the above-identified compound.

Provenance & Evidence