Trimethylamine → HCID 14376353, compound

HRID 868443Notes

Reaction equation

HRID 868443 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]([O:5][CH:6]([CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:7][OH:8])=[O:4].[P:30](Cl)([O-:44])([O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]Br)=[O:31].[CH3:46][N:47]([CH3:49])[CH3:48]>>[P:30]([O-:44])([O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][N+:47]([CH3:49])([CH3:48])[CH3:46])([O:8][CH2:7][CH:6]([O:5][C:3](=[O:4])[N:2]([CH3:29])[CH3:1])[CH2:9][O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:31]

Participants

4

Reactant 3

HCID 1146TrimethylamineHCID 143763521-Hydroxy-3-(octadecyloxy)propan-2-yl dimethylcarbamateHCID 86742486HCID 86742486, compound

Product 1

HCID 14376353HCID 14376353, compoundYield 61.3%

Procedure

In accordance with Example 7, 2.49 g of 2-dimethylcarbamoyloxy-3-octadecyloxypropanol, 3.17 g of 10-bromodecyl chlorophosphate and trimethylamine were used for reaction and purification to give 2.55 g (yield: 61.3%) of the desired product.

Sources & evidence

ORD record
ord-9986c76551bd445294b6ab58cfa8bac9
Source dataset
uspto-grants-1988_10
Patent number
US04778912

Reaction notes

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