Trityl chloride → HCID 21288382, compound

Participants

Reaction Steps

A mixture of 2.0 g (6.06 mmole) of 1-(15-methylhexadecyloxy)-2,3-propanediol, 2.54 g (9.09 mmole) of trityl chloride and 20 ml of pyridine was stirred at room temperature for 2 days, and then pyridine was distilled off. To the residue was added 50 ml of ethyl acetate and the ethyl acetate solution was washed with 1N hydrochloric acid, water and saturated sodium bicarbonate solution, in order, and dried over anhydrous magnesium sulfate. The desiccating agent was filtered off and the filtrate was concentrated under reduced pressure. The residue was subjected to column chromatography on silica gel (100 g) and eluted with hexane-ethyl acetate (20:1) to give 2.3 g of crude 1-(trityloxy)-3-(15-methylhexadecyloxy)-2-propanol. This product was treated by following the procedure of that of Reference Example 12 to give 1.0 g (yield: 39%) of the desired product.

Provenance & Evidence