反应详情

温度

130 °C

To 7-chloro-3H-imidazo(4,5-b)pyridine (16 g, 97 mmol) was added aniline (200 mL, 2.1 mol). The resulting mixture was heated under a nitrogen atmosphere at 130° C. for 24 hours. Benzene was added to the cooled mixture and the precipitate was filtered. The solid was dissolved in water and 1N NaOH was added to give a pH reading of 9. The precipitate was filtered and recrystallized from EtOH (decolorized by charcoal) to give 7.2 g (35%) of the 7-anilino-3H-imidazo[4,5-b]pyridine, m.p. 251°-252° C.

1. filtrationthe precipitate was filtered
2. dissolutionThe solid was dissolved in water
3. addition1N NaOH was added
4. customto give a pH reading of 9
5. filtrationThe precipitate was filtered
6. customrecrystallized from EtOH (decolorized by charcoal)