Oxalic Acid → HCID 14062129, compound

HRID 868528Notes

Reaction equation

HRID 868528 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[CH2:13].[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27]>C(OCC)C>[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27].[Cl:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[CH2:13]

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 14062128HCID 14062128, compound

Product 1

HCID 14062129HCID 14062129, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2-[2-(2,4-Dichlorobenzyloxy)phenyl]-3-(imidazol-1-yl)-1-propene (98.9 g, 0.275 mole) was dissolved in diethyl ether (200 ml) and a solution of oxalic acid (24.79 g, 0.275 mole) in diethyl ether was added thereof with stirring. The solvent was distilled off under reduced pressure and the residue was recrystallized from methanol-diethyl ether to obtain the title compound (103.5 g, 83.8%), m.p. 131°-132° C.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-60a819d3eba241f383d13f349e6f4e9c
Source dataset
uspto-grants-1988_10
Patent number
US04780471

Reaction notes

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