1H-1,2,4-Triazole → HCID 21287215, compound

Participants

Reaction Steps

1,2,4-Triazole (59 mg, 0.854 mmole) and potassium carbonate (129 mg, 0.933 mmole) were suspended in dimethylformamide (1 ml) and a solution of 2-[2-(2,4-dichlorobenzyloxy)phenyl]-3-bromo-1-propene (290 mg, 0.779 mmole) in dimethylformamide (2 ml) was added dropwise to the suspension. Then, after stirring overnight at room temperature, the reaction mixture was worked up according to the same manner as in Example 25 to obtain the title compound (0.20 g, 71.2%). By comparing 1H-NMR and Rf value of TLC of the resulting compound with those of the product of the alternative process described in Example 34, it was confirmed that both chemical structures were identical with each other.

Provenance & Evidence