Imidazole → HCID 21287220, compound

Participants

Reaction Steps

1H-Imidazole (10.21 g, 150 mmole) was dissolved in dimethylformamide (20 ml) and ω-bromo-2-(2,4-dichlorobenzyloxy)acetophenone (11.2 g, 29.9 mmole) was added slowly. After stirring for 2.5 hours with ice-cooling, water (120 ml) was added and the mixture was extracted with ethyl acetate (120 ml×2). The extract was washed with water (120 ml×2) and dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, the residue was subjected to chromatography on a silica gel columne and eluted with methanol/chloroform to obtain the title compound (8.37 g, 77.2%), m.p. 109°-111° C. (recrystallized from n-hexane/benzene).

Provenance & Evidence