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Sodium Hydroxide → 7-(1-Phenyl-3-dimethylaminopropoxy)-isoflavone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 7-Hydroxyisoflavone | HCID 5376891 | — |
| 反応物 | 3-Chloro-N,N-dimethyl-3-phenylpropan-1-amine | HCID 12707239 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 7-(1-Phenyl-3-dimethylaminopropoxy)-isoflavone | HCID 12918914 | — |
反応手順
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 23.8 g of 7-hydroxyisoflavone in 100 ml of CH2Cl2, 20 g of 1-chloro-1-phenyl-3-dimethylaminopropane is added dropwise while stirring and stirring is continued for a further hour. Working up in the customary manner gives 7-(1-phenyl-3-dimethylaminopropoxy)-isoflavone. M.p. 128°-130°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04780478 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-b0358f963c294462a6e573785cc0d55e |
| 出典メモ | uspto-grants-1988_10 |