1-(3-Chlorophenyl)piperazine monohydrochloride → 8-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione hydrochloride hemihydrate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(3-Chlorophenyl)piperazine monohydrochloride	HCID 25681	—
Edukt	8-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione	HCID 14280583	—
Lösungsmittel	Triethylamine	HCID 8471	—
Produkt	8-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione hydrochloride hemihydrate	HCID 131715732	—

Reaktionsschritte

A solution of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g) and 1-(3-chlorophenyl)piperazine hydrochloride (3.06 g) in 50 ml of Et3N was heated to reflux with stirring under N2. After 1 hour TLC (thin layer chromatography) showed the absence of starting material. The excess Et3N was removed in vacuo and the residue chromatographed on silica using ethyl acetate as the eluent. Fractions containing the desired product were combined and concentrated in vacuo.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04780466
Quelldatensatz	uspto-grants-1988_10
ORD ID	ord-1ba4e93a36a248379f4efa5efff7e99b
Quellennotiz	uspto-grants-1988_10