5-Methylisatin → 1-(3-Diisopropylaminopropyl)-5-methylisatin

HRID 868569Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].Cl.[CH:14]([N:17]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:19][CH2:20]Cl)([CH3:16])[CH3:15]>>[CH:14]([N:17]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:19][CH2:20][N:7]1[C:8]2[C:4](=[CH:3][C:2]([CH3:1])=[CH:10][CH:9]=2)[C:5](=[O:12])[C:6]1=[O:11])([CH3:16])[CH3:15]

Participants

Reactant 2

HCID 118405-Methylisatin

HCID 197430953-Diisopropylaminopropyl chloride hydrochloride

Product 1

HCID 139344231-(3-Diisopropylaminopropyl)-5-methylisatin

Procedure

By using 5-methylisatin and 3-diisopropylaminopropyl chloride hydrochloride, a method analogous to that described in Reference Example 1 was carried out to obtain 1-(3-diisopropylaminopropyl)-5-methylisatin having a melting point of 87°-89° C. (yeld: 53.3%).

Sources & evidence

ORD record: ord-34493ab19c834d048155f2575c391ae1
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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