Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | n-methylhydrazinecarboxamide | HCID 256005 | — |
| Reactant | 1-(2-Diisopropylaminoethyl)isatin | HCID 13934408 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178485945 | HCID 178485945 | 49.9% |
Reaction Steps
To a solution of 1.37 g of 1-(2-diisopropylaminoethyl)isatin and 0.49 g of 4-methylsemicarbazide in ml of a mixture of ethanol and water (2:1) was added 3 drops of acetic acid, and then the mixture was heated at 60° C. for 6 hours. The yellow precipitates were collected by filtration and recrystallized from aqueous ethanol to obtain 0.86 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-(4-methylsemicarbazone) having a melting point of 175°-177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04780477 |
|---|
| Source dataset | uspto-grants-1988_10 |
|---|
| ORD ID | ord-5fbf79bed12049c6bee72c63a9ec2225 |
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| Source note | uspto-grants-1988_10 |
|---|
